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Patient Derived Organoids

Culturing Patient Derived Explants (PDE)

FDA promotes MPS platforms for efficiency of drug development and reduced vivisection

Computational studies have been used to identify hotpot mutation sequences of SARS-CoV-2. PerfusionPal is being used for molecular studies of SARS-CoV-2

3D cell culturing systems offer new methods to evaluate organ activity and close the gap between 2D cell culture and animal models

Prediction of patient response to treatment by testing on tissue outside of patients body

In vitro brain organoids lead to improved research avenues. They allow scientists to develop biologically appropriate microenvironments

The study of inflammatory bowel disease (IBD) can be challenging due to the lack of human models. Intestinal organoids generated from patient tissue can be used to develop personalized therapies.

Common colon cancer treatments include surgical procedures, radiation therapy, and systemic chemotherapy and immunotherapy. There is a need for more personalized treatment options for improving results from colon cancer therapies and reducing the chance of reoccurrence.

Colorectal Cancer (CRC) studies mostly involve animal models, but 3D organoid models provide a promising alternative as they better recapitulate disease conditions and cancer environments in humans

PerfusionPal 3D is a MPS platform that enables growth and screening of 3D mono-cultures with perfusion. PerfusionPal can be used to predict liver toxicity caused by a drug early in the development process.